Peyronie’s disease

Peyronie’s disease is a deformity of the penis during an erection. The main cause of the disease is the onset of a painful process in the tunica albuginea and the septum of the cavernous bodies of the penis. The etiology of this process has not yet been identified.

There are only three main signs of the disease:

Penile pain, both at rest and during erection, is the primary symptom of Peyronie’s disease.
Plaque formation on the penis
Fibrous plaques are localized on the upper (dorsal) surface of the penis. They look like dense knots, strands and plates. The plaques are sharply limited, painless. The size of the plaques is 0.5-1.5 cm, the thickness is 2-5 mm. The plaques are localized at different depths, the skin under them is mobile and not changed. Their occurrence is most typical at the root of the penis, sometimes in the central part, less often at the head.

The consequence of the manifestations of Peyronie’s disease is a curvature of the penis, which makes it difficult or even impossible to have sexual intercourse.
Peyronie’s disease should be distinguished from cavernitis, periurethritis, post-traumatic deformity of the penis.

Peyronie’s disease can be treated conservatively as well as operatively.

In conservative therapy, complex treatment is most effective:

The use of cortisone (in the form of injection or by mouth) reduces inflammation associated with reactions in cells.

Also, according to some data, the use of enzyme preparations, for example, lidase, and biogenic stimulants is not devoid of efficiency.

Physiotherapy is used in a complex way: diametry, electrophoresis, dyadic currents.

More recently, ultrasound therapy has been used to treat Peyronie’s disease. Sessions of 5-7 minutes should be done every other day. The course of treatment is 20-25 sessions.

The use of X-ray therapy has shown low efficacy and risk of complications.


The main indication for surgery for Peyronie’s disease is such a curvature of the penis, which makes intercourse difficult. Also, the operation can be performed in case of severe pain or in case of ineffectiveness of complex treatment for a long time.

The condition for the operation is a relatively shallow location of the plaques, as well as their sufficient mobility.

Without treatment, Peyronie’s disease almost never goes away, as the plaques tend to grow in size and number.