Buy Aceon online without prescription. 💕
>>> Buy now Aceon<<<
👍 Discount 10%.
Active Ingredient: Perindopril Erbumine.
💚Aceon is used for treating high blood pressure.
Acertil, Acerycal, Agulan, Aldoc, Apo-perindox, Armix, Asyntilsan, Bionoliprel, Biprel, Bipreterax, Cardipen, Co-prenessa, Co-prestarium, Cobathrow, Coveram, Coverene, Coverex, Coverex-as, Coversum, Covinace, Domanion, Dorover, Indapril, Inopil, Midopril, Noliprel, Pendoril, Pendrex, Percarnil, Perindal, Perindan, Perindo, Perindox, Prenessa, Prenix n, Prestance, Prestarium, Preterax, Prexanil, Prexanil a, Prexum, Prindace, Procaptan, Provinace, Reaptan, Repres plus, Spopress, Stopress, Teraxans, Tertensif kombi, Vectoryl, Vidotin.
Indications for use are narrow-profile for a therapeutic hospital due to the specificity of the therapeutic effect of the drug Perindopril:
☞chronic heart failure;
☞hypertension of renovascular etiology;
☞prevention of recurrent stroke or stroke after a transient ischemic attack;
☞stable ischemic heart disease.
👉Indications for useComposition
☞perindopril erbumin (acts as the main active ingredient) – 4 mg;
☞milk sugar (lactose);
☞microcrystalline cellulose (MCC);
☞croscarmellose or primellose sodium;
Perindopril is a pharmaceutical product that belongs to the group of angiotensin-converting enzyme inhibitors. Due to the chemical interaction of this catalyst with zinc ions, it is completely inactivated. As a result of such influences, the conversion of angiotensin I to angiotensin II, which has a vasoconstrictor effect, is inhibited (due to the narrowing of the vascular bed, blood pressure rises). Suppression of ACE is accompanied by effects on the kallikrein-kinin system and prostaglandins – their circulating and tissue concentrations increase.
The drug is used orally, after which 25 percent of the constituent components are absorbed from the cavity of the gastrointestinal tract. Bioavailability of the drug is 65-70 percent. Interesting and even somewhat unusual is the time to reach maximum plasma concentration. The largest number of inactive substances reaches 1 hour, and the biologically active perindoprilat, the product of the active ingredient exchange in the internal environment of the body (about 20 percent of Perindopril is metabolized to this form), manifests its extreme abilities only 3-4 hours after taking the medicine.
☞increased individual sensitivity, acquired or inherited intolerance to the constituent components of a pharmaceutical preparation or the whole group of angiotensin-converting enzyme inhibitors;
☞lactation or breastfeeding;
☞angioedema of hereditary or idiopathic origin;
☞the drug is not used in pediatric practice (until the age of 18).
☞aortic or mitral stenosis;
☞severe autoimmune nosological units of the connective tissue (in particular, systemic lupus erythematosus or scleroderma);
☞the presence of a transplanted donor kidney;
☞obliterating atherosclerosis or narrowing of the lumen of vessels of other origin (especially the channel feeding the heart muscle);
☞bilateral stenosis of the renal arterioles;
☞moderate or severe renal failure;
☞dehydration and exsiccosis.
Perindopril is an extremely active pharmaceutical drug, which, in addition to therapeutic effects, is indicated by the frequency of adverse reactions during treatment. It makes up 1-10 percent of all cases of conservative therapy. The side effect of the constituent components can manifest itself in the form of a violation of various body systems:
Since the cardiovascular system: excessive reduction in blood pressure with the development of orthostatic hypotension, arrhythmia, angina, stroke and myocardial infarction.
On the part of the urinary system: reduced functional ability of the kidneys, acute renal failure.
Respiratory organs: dry cough, rhinorrhea, difficulty in inhaling and exhaling, eosinophilic pneumonia, bronchospasm.
On the part of the central nervous system: headache, asthenia, dizziness, fatigue, imbalance of sleep and wakefulness, decreased mood, periodic tinnitus, disorders of the visual apparatus, muscle cramps and paresthesia.
Allergic reactions: pruritus or rash, urticaria, angioedema, erythema multiforme.
From other systems: increased sweating, impaired sexual function.
Changes in laboratory parameters – hypercreatininemia, hypohemoglobinemia, thrombocytopenia, proteinuria, hyperkalemia, hyperuricemia, neutropenia, leukopenia (agranulocytosis), pancytopenia, increased percentage and activity of liver enzymes, hemolytic anemia in the presence of glucose-6-phosphate-6-phospholiphoma-6-phosphorus, and hemolytic anemia, an increase in the percentage ratio and activity of liver enzymes.
Pharmaceutical drug is used orally at a time (once a day). Treatment usually starts with a starting dosage of 1-2 mg per day. Further, depending on the indications for therapy, the instructions for use of Perindopril are somewhat different:
✧arterial hypertension can be treated with higher amounts of the medication taken, with this pathology 4-8 mg per day is used, the dosage should be increased gradually, within 3-4 weeks;
✧renovascular hypertension is treatable at 2 mg per day;
✧prevention of stroke is carried out according to a special scheme: first, 2 mg per knock for 2 weeks, and then 4 mg per day for the same length of time;
✧therapy of stable coronary heart disease begins with a starting dose of 4 mg per day for 2 weeks, and then the amount of the drug taken increases to 8 mg per day.
☞excessive lowering of blood pressure;
☞horizontal position with a raised lower end to restore blood pressure;
☞the use of enterosorbents;
☞correction of water and electrolyte balance isotonic solution of sodium chloride;
☞atropine in the development of bradycardia;
☞effectively using hemodialysis (use of highly permeable polyacrylonitrile membranes is not recommended);
☞in a particularly severe pathological picture of overdose, implantation of an artificial pacemaker can be used.
☞agents used for anesthesia;
☞anti hypertensive drugs of any mechanism of action;
☞loop and thiazide diuretics;
☞antipsychotic drug group;
☞non-selective monoamine reuptake inhibitors.
☞Indomethacin may have the opposite effect, that is, a decrease in the hypotensive effect.
Conserve Perindopril should be dry, out of the reach of children, and protected from direct sunlight. The temperature regime of optimal storage should not exceed 25 degrees Celsius.
When using ACE inhibitors and Perindopril in particular, there is a risk of arterial hypotension, headache, dizziness and visual impairment, therefore during the period of conservative treatment it is worth refusing to independently control vehicles or other activities that require increased attention, speed and clarity of motor reactions.
Perindopril Indapamide Richter is an enhanced form of the previous analog. The effect of the drug lasts for 24 hours, and persistent therapeutic effects develop in less than a month of conservative treatment. It should be emphasized that the termination of drug rehabilitation when using this form of medication is not accompanied by withdrawal syndrome, which is sometimes extremely difficult.
Perindopril Arginine is a unique medicine of its kind, because the constituent components of the antihypertensive agent are supplemented with conditionally essential amino acid, the main role of which is to be a source of NO synthase in the process of producing endogenous nitric oxide. The latter is an extremely active mediator of the organism in the pathophysiological sense. In this context, the most important are its vasodilation abilities and the regulating effects on smooth muscle tone. Thus, the hypotensive effect of the drug covers a much wider mechanism of action than Perindopril in its pure form. It should be noted that this drug combination does not prolong the list of side effects of use, since arginine is part of the natural metabolism of the human body.
Amlodipine Perindopril is a pharmaceutical product that includes another slow calcium channel blocker, a dihydropyridine derivative. In addition to the antihypertensive effect, Amlodipine also has an antianginal effect, since, by binding to the dihydropyridine receptors, it reduces the transmembrane current of calcium in smooth muscle cells of the coronary and peripheral beds. This mechanism of action and the consequences of its use put this drug in the first place among the analogues of Perindopril for indications for the treatment of coronary heart disease and angina in particular.
Perindopril-Mik is a Belarusian equivalent of a domestic pharmaceutical product. A key feature of it is the use of Perindopril t-butylamine salt (in the traditional form of the drug, a compound with erbumin is used). Due to this fact, the drug reduces pressor effects on the vascular wall (including adrenergic), which manifests itself as an angioprotective effect. It should also be noted that the therapeutic effects of this combination extend to peripheral tissues to a greater extent – they are sensitized to insulin, and therefore glucose metabolism proceeds with greater intensity.
The drug is not used in pediatric practice until the age of 18.
While undergoing a course of conservative drug therapy, alcoholic beverages should be completely excluded, since alcohol increases the hypotensive effect of the drug, which can adversely affect the body and lead to serious consequences (sudden loss of consciousness, acute cerebral or coronary circulation insufficiency, and so on).
Perindopril is contraindicated for use during periods of pregnancy, lactation or breastfeeding.
Messages on pharmaceutical forums unanimously reiterate the positive effect of the drug on blood pressure parameters and the work of the heart as a whole. Such an active active ingredient of Perindopril can cope with serious pathology in a relatively short course of conservative therapy. People who took a pharmaceutical drug speak very well about it, because in addition to the main therapeutic effects, it improves trophism and the delivery of beneficial nutrients to all peripheral tissues and organs, cleans the macro circulatory bed, which can not but affect the overall well-being .